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Doxercalciferol

 - Hectorol  - TSA 840
Axon 1746
CAS:  54573-75-0
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C28H44O2
  • MW:  412.65

Description

Doxercalciferol is a vitamin D2 analogue with vitamin D receptor (VDR) agonist activity.

VDR activation regulates calcium and phosphate homeostasis, parathyroid hormone biology and transcriptional programs linked to differentiation and mineral metabolism. Doxercalciferol is useful as a vitamin D receptor pharmacology reference compound.

Key Features

  • Vitamin D2 analogue with VDR agonist activity
  • Activates vitamin D receptor-dependent transcription
  • Relevant to calcium and phosphate homeostasis pathways
  • Clinically relevant mineral metabolism pharmacology

Applications

  • VDR nuclear receptor assays
  • Calcium and phosphate metabolism research
  • Parathyroid hormone pathway studies
  • Vitamin D analog pharmacology

More Information

Parent CAS No. 54573-75-0
Chemical Name (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
SMILES [C@]12(C)CCC/C(=CC=C3C[C@H](C[C@H](O)C3=C)O)/[C@]1([H])CC[C@@H]2[C@H](C)/C=C/[C@H](C)C(C)C |&1:0,10,12,17,21,22,26,r|
MFCD N.A.
InChi InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChiKey HKXBNHCUPKIYDM-CGMHZMFXSA-N
CID 5281107
Short Description VDR agonist

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