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Eltoprazine hydrochloride
- DU 28853
Axon 1142
- Parent CAS: 98224-03-4
Purity:
99%
- Soluble in water and DMSO
- MF: C12H16N2O2.HCl
- MW: 256.73
Description
5-HT1A/1B agonist and 5-HT2C receptor antagonist. Following L-DOPA challenge, Eltoprazine causes a significant reduction of L-DOPA-induced dyskinesias.
More Information
| Parent CAS No. | 98224-03-4 |
|---|---|
| Chemical Name | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazine hydrochloride |
| SMILES | C1C2OCCOC=2C(N2CCNCC2)=CC=1.Cl |
| MFCD | MFCD06245586 |
| InChi | InChI=1S/C12H16N2O2.ClH/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12;/h1-3,13H,4-9H2;1H |
| InChiKey | JFSOSUNPIXJCIX-UHFFFAOYSA-N |
| CID | 3025067 |
| Short Description | 5-HT1A/1B agonist |
References
- G Griebel et al. Serenics fluprazine (DU 27716) and eltoprazine (DU 28853) enhance neophobic and emotional behaviour in mice. Psychopharmacology 1990, 102, 498-502.
- DR. Cherek et al. Acute effects of eltoprazine on aggression and point-mantained responding of normal male participants: Phase I study. Exp. Clin. Psychopharmacol. 1995, 3/3, 287-293.
- P. Svenningsson et al. Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study. Brain. 2015 Feb 10. pii: awu409. [Epub ahead of print]
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