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Rotigotine
- N 0923
Axon 1040
CAS:
99755-59-6
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C19H25NOS
- MW: 315.47
Description
Rotigotine is a dopamine D2/D3 receptor agonist and the more active enantiomer of N-0437 compared with the opposite R-enantiomer N-0924. It is widely used as a dopaminergic agonist reference compound.
D2 and D3 receptor activation is relevant to Parkinsonian motor circuitry, reward pathways and dopaminergic neuropharmacology. Rotigotine is valuable for experiments that require a well-characterized dopamine agonist with D2/D3 activity.
Key Features
- Dopamine D2 and D3 receptor agonist
- More active enantiomer of N-0437
- Non-ergoline dopaminergic ligand
- Useful reference compound for dopamine agonist studies
Applications
- D2/D3 receptor pharmacology
- Parkinson's disease pathway research
- Dopaminergic neurotransmission studies
- Comparative dopamine agonist profiling
More Information
| Parent CAS No. | 99755-59-6 |
|---|---|
| Chemical Name | (S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol |
| SMILES | C1C=C2C[C@@H](N(CCC)CCC3=CC=CS3)CCC2=C(O)C=1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3 |
| InChiKey | KFQYTPMOWPVWEJ-UHFFFAOYSA-N |
| CID | 57537 |
| Short Description | DA agonist |
References
- J van der Weide et al. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. Eur. J. Pharmacol. 1986, 125, 273-282.
- M.Y. Splinter. Rotigotine: Transdermal Dopamine Agonist Treatment of Parkinson's Disease and Restless Legs Syndrome. Ann. Pharmacother. 2007, 41, 285-295.
- . Jenner et al. A novel dopamine agonist for the transdermal treatment of Parkinson’s disease. Neurology. 2005, 65, S3-S5.
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