(S)-(-)-8-Hydroxy-DPAT hydrobromide - (S)-(-)-8-OH-DPAT

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1017

CAS [78095-20-2]

MF C16H25NO.HBr
MW 328.29

Purity: 98%
Optical purity: 98% ee
Soluble in DMSO

(S)-(-)-8-Hydroxy-DPAT hydrobromide

Description

5-HT1A receptor partial agonist, less active enantiomer of (±)-8-OH-DPAT (Axon 1015), in comparison with R-(+)-8-hydroxy-DPAT (Axon 1016) as a full 5-HT1A agonist

T Yoshitake and J Kehr. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004, 74, 2865.

LJ Cornfield et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 1991, 39, 780.

CNS 5-HT1A A19

5-HT1A agonist

Chemical name

(S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide

Parent CAS No.

[80300-10-3]

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(S)-(-)-8-Hydroxy-DPAT hydrobromide - (S)-(-)-8-OH-DPAT

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(S)-(-)-8-Hydroxy-DPAT hydrobromide - (S)-(-)-8-OH-DPAT

Description

Chemical name

Parent CAS No.

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