Bulk Inquiry
(S)-(-)-8-Hydroxy-DPAT hydrobromide
- (S)-(-)-8-OH-DPAT
Axon 1017
- Parent CAS: 80300-10-3
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C16H25NO.HBr
- MW: 328.29
Description
(S)-(-)-8-Hydroxy-DPAT hydrobromide is the less active S-(-)-enantiomer of 8-Hydroxy-DPAT (Axon 1015) and is described as a partial 5-HT1A receptor agonist. It is useful for comparing partial versus full 5-HT1A receptor agonism.
Partial agonists at 5-HT1A receptors can produce distinct signaling profiles compared with full agonists. (S)-(-)-8-Hydroxy-DPAT hydrobromide is valuable for stereoselectivity studies and for dissecting efficacy-dependent serotonergic responses.
The more active (R)-(+)-8-Hydroxy-DPAT hydrobromide is available as Axon 1016.
Key Features
- Partial 5-HT1A receptor agonist
- Less active enantiomer of racemic 8-OH-DPAT
- Comparator for R-(+)-8-OH-DPAT full agonism
- Useful for efficacy and stereochemistry studies
Applications
- 5-HT1A receptor pharmacology
- Partial agonism studies
- Serotonergic GPCR signaling assays
- Enantiomer comparison experiments
More Information
| Parent CAS No. | 80300-10-3 |
|---|---|
| Chemical Name | (S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide |
| SMILES | C1C(O)=C2C[C@@H](N(CCC)CCC)CCC2=CC=1.Br |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1 |
| InChiKey | BATPBOZTBNNDLN-UQKRIMTDSA-N |
| CID | 10125796 |
| Short Description | 5-HT1A agonist |
References
- T Yoshitake and J Kehr. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004, 74, 2865.
- LJ Cornfield et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 1991, 39, 780.
