NM-3
Axon N0045
CAS:
181427-78-1
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C13H12O6
- MW: 264.23
Description
Antitumor agent€ angiogenesis inhibitor.******Source information: Synthetic analogue of Cytogenin
More Information
| Parent CAS No. | 181427-78-1 |
|---|---|
| Chemical Name | 2-(8-Hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propanoic acid |
| SMILES | C1(OC)C=C2C=C(C(C)C(=O)O)OC(=O)C2=C(O)C=1 |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | Antitumor, angiogenesis inhibitor |
References
- N Matsumoto et al. Synthesis and biological evaluation of cytogenin derivatives. J Antibiot (Tokyo). 2001 Mar;54(3):285-96.
- T Tsuchida et al. Convenient total synthesis of NM-3, an antiangiogenesis agent, and its optical resolution. J Antibiot (Tokyo). 2003 Jan;56(1):38-41.
- T Nakashima et al. Inhibition of angiogenesis by a new isocoumarin, NM-3. J Antibiot (Tokyo). 1999 Apr;52(4):426-8.
- RM Salloum et al. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15;60(24):6958-63.
- CL Reimer et al. Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res. 2002 Feb 1;62(3):789-95.
- N Agata et al. The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol. 2005 Dec;56(6):610-4.
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