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S3QEL 2
Axon 2544
CAS:
890888-12-7
Purity:
99%
- Soluble in DMSO
- MF: C19H25N5
- MW: 323.44
Description
Suppressor of superoxide production from mitochondrial complex III (IC50 value 1.7 µM against superoxide production mediated by the outer Q-binding site of complex III (site IIIQo)). S3QEL-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells, and strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets. S3QEL-2 modulates HIF-1α activation without directly affecting metabolism.
More Information
| Parent CAS No. | 890888-12-7 |
|---|---|
| Chemical Name | 1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| SMILES | C1=NC(N(CCC)CCC)=C2C=NN(C3=CC=C(C)C(C)=C3)C2=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3 |
| InChiKey | MGIAJZSCNPODRR-UHFFFAOYSA-N |
| CID | 17017624 |
| Short Description | Complex III modulator |
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