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BX 430
Axon 2523
CAS:
688309-70-8
Purity:
99%
- Soluble in DMSO
- MF: C15H15Br2N3O
- MW: 413.11
Description
Noncompetitive, allosteric antagonist of human P2X4 receptor channels (IC50 value 0.54 μM as determined by Patch-clamp electrophysiology) with 10-100 fold selectivity over P2X1–P2X3, P2X5, and P2X7. A useful molecular probe to assess the specific role of P2X4 in inflammatory and neuropathic conditions, where ATP signaling has been shown to be dysfunctional. BX430 has no effect on mouse and rat P2X4Rs.
More Information
| Parent CAS No. | 688309-70-8 |
|---|---|
| Chemical Name | 1-(2,6-dibromo-4-isopropylphenyl)-3-(pyridin-3-yl)urea |
| SMILES | N(C1=C(Br)C=C(C(C)C)C=C1Br)C(NC1=CC=CN=C1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21) |
| InChiKey | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| CID | 2810999 |
| Short Description | P2X4 antagonist |
References
- A.R. Ase et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16.
- K.A. Jacobson et al. Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology. 2015 Dec 12. pii: S0028-3908(15)30197-0. doi: 10.1016/j.neuropharm.2015.12.001.
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