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ABH
Axon 4414
CAS:
222638-65-5
- Optical Purity: 99.3% e.e.
- Soluble in water and DMSO
- MF: C6H14BNO4
- MW: 174.99
Description
ABH is a highly potent and specific inhibitor of arginase with a Ki value of 8.5 nM.
More Information
| Parent CAS No. | 222638-65-5 |
|---|---|
| Chemical Name | (S)-2-Amino-6-(dihydroxyboryl)hexanoic acid |
| SMILES | C(=O)(O)[C@@H](N)CCCCB(O)O |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 |
| InChiKey | HFKKMXCOJQIYAH-YFKPBYRVSA-N |
| CID | 9793992 |
| Short Description | Arginase inhibitor |
References
- R Baggio et al. Inhibition of Mn2+2-Arginase by Borate Leads to the Design of a Transition State Analogue Inhibitor, 2(S)-Amino-6-boronohexanoic Acid. J. Am. Chem. Soc. 1997 Aug 27;119(34):8107-8108.
- SL Kavalukas et al. Arginase inhibition promotes wound healing in mice. Surgery. 2012 Feb;151(2):287-95.
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