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iMDK
Axon 2258
CAS:
881970-80-5
Purity:
99%
- Soluble in DMSO
- MF: C21H13FN2O2S
- MW: 376.4
Description
MDK expression inhibitor; iMDK inhibits specifically and dose-dependently the expression of Midkine (MDK) in H441 lung adenocarcinoma cells, but does not inhibit PTN (Pleiotrophin), which has considerable homology to MDK. iMDK induces apoptotosis in MDK-expressing H441 lung adenocarcinoma cells by suppression of the PI3K/Akt pathway but not the MAPK pathway. iMDK does not inhibit another growth factor VEGF.
More Information
| Parent CAS No. | 881970-80-5 |
|---|---|
| Chemical Name | 3-(2-(4-fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one |
| SMILES | C1(=O)OC2=CC=CC=C2C=C1C1=CN2C=C(CC3=CC=C(F)C=C3)SC2=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H13FN2O2S/c22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25/h1-8,10-12H,9H2 |
| InChiKey | IWFKQTWYILKFGE-UHFFFAOYSA-N |
| CID | 15991416 |
| Short Description | Midkine expression inhibitor |
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