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TUPS
Axon 3022
CAS:
950184-27-7
Purity:
100%
- Soluble in DMSO
- MF: C14H18F3N3O4S
- MW: 381.37
Description
TUPS is a soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 3 nM for recombinant human sEH. TUPS prevents isoproterenol (ISO)-induced cardiac hypertrophy.
More Information
| Parent CAS No. | 950184-27-7 |
|---|---|
| Chemical Name | 1-(1-(Methylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea |
| SMILES | C1(OC(F)(F)F)C=CC(NC(=O)NC2CCN(S(=O)(=O)C)CC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H18F3N3O4S/c1-25(22,23)20-8-6-11(7-9-20)19-13(21)18-10-2-4-12(5-3-10)24-14(15,16)17/h2-5,11H,6-9H2,1H3,(H2,18,19,21) |
| InChiKey | YORLNOBDSZJFQQ-UHFFFAOYSA-N |
| CID | 25093353 |
| Short Description | sEH inhibitor |
References
- N Chiamvimonvat et al. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol. 2007 Sep;50(3):225-37.
- B Inceoglu et al. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5093-7.
- H Zhang et al. Soluble epoxide hydrolase inhibitor, TUPS, attenuates isoproterenol/angiotensin II-induced cardiac hypertrophy through mammalian target of rapamycin-mediated autophagy inhibition. J Pharm Pharmacol. 2019 Aug;71(8):1291-1300.
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