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Org OD 02-0
- 19-CH2P4
Axon 2085
CAS:
13258-85-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H30O2
- MW: 326.47
Description
Selective agonist of membrane progesterone receptor (mPR; IC50 value 33.9 nM). Org OD 02-0 mimics the protective effects of progestin hormones on serum starvation-induced cell death and apoptosis in both granulosa and breast cancer cells without altering caspase 3 activity. Org OD 02-0 significantly increased mitochondrial membrane potential (MMP) in serum starved MB468 cells.
More Information
| Parent CAS No. | 13258-85-0 |
|---|---|
| Chemical Name | (8S,9S,10S,13S,14S,17S)-17-acetyl-13-methyl-10-vinyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| SMILES | C1(=O)C=C2[C@](C=C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2 |&1:4,9,11,13,15,19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H30O2/c1-4-22-12-9-16(24)13-15(22)5-6-17-19-8-7-18(14(2)23)21(19,3)11-10-20(17)22/h4,13,17-20H,1,5-12H2,2-3H3/t17-,18+,19-,20-,21+,22-/m0/s1 |
| InChiKey | VFNRBPBEOXXVPX-GCOBIYGJSA-N |
| CID | 22212907 |
| Short Description | mPR agonist |
References
- J. Kelder et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative (...). Steroids. 2010, 75, 314-322.
- G.E. Dressing et al. Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors. Horm. Cancer. 2012, 3, 101-112.
- P. Thomas et al. Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells. Neuroendocrinology. 2012, 96, 162-171.
- List of publications using Org OD 02-0 (Axon 2085) purchased from Axon Medchem
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