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Atrasentan
- A127722 - ABT627
Axon 4058
CAS:
173937-91-2
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C29H38N2O6
- MW: 510.62
Description
Atrasentan is a highly potent, selective, and orally active ETA-selective endothelin receptor antagonist with an IC50 value of 0.055 nM.
More Information
| Parent CAS No. | 173937-91-2 |
|---|---|
| Chemical Name | (2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid |
| SMILES | C(=O)(N(CCCC)CCCC)CN1[C@@H](C2C=CC(OC)=CC=2)[C@H](C(=O)O)[C@@H](C2C=C3OCOC3=CC=2)C1 |&1:13,22,26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1 |
| InChiKey | MOTJMGVDPWRKOC-QPVYNBJUSA-N |
| CID | 159594 |
| Short Description | ETA antagonist |
References
- M Winn et al. 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. J Med Chem. 1996 Mar 1;39(5):1039-48.
- TJ Opgenorth et al. Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist. J Pharmacol Exp Ther. 1996 Feb;276(2):473-81.
- JL Wessale et al. Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies. Clin Sci (Lond). 2002 Aug;103 Suppl 48:112S-117S.
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