Order

Size
Price
Stock
Qty

BMS-986365

 - CC-94676
Axon 4232
CAS:  2446928-30-7
  • Optical Purity:  Optically pure
  • Soluble in DMSO and EtOH
  • MF:  C41H45F3N8O5S
  • MW:  818.91

Description

BMS-986365 is a highly potent and selective androgen receptor (AR) degrader that induces rapid and deep degradation of both wildtype and mutant forms of the receptor residing in either the cytoplasmic or nuclear compartments of the cell. Moreover, BMS-986365 is a ligand-directed degrader (LDD) that enables the CRL4CRBN E3 ligase-dependent ubiquitination and degradation of AR (DC50 10 to 40 nM, Ymin 7 to 19%).

More Information

Parent CAS No. 2446928-30-7
Chemical Name 2-((R)-4-(2-(4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-ethylphenoxy)ethyl)-2-methylpiperazin-1-yl)-N-(3-(2,6-dioxopiperidin-3-ylamino)phenyl)acetamide
SMILES C1CN(CC(NC2C=C(NC3CCC(=O)NC3=O)C=CC=2)=O)[C@H](C)CN1CCOC1C=CC(N2C(C)(C)C(=O)N(C3C=CC(C#N)=C(C(F)(F)F)C=3)C2=S)=CC=1CC |&1:22,r|
MFCD N.A.
InChi InChI=1S/C41H45F3N8O5S/c1-5-26-19-31(52-39(58)51(38(56)40(52,3)4)30-10-9-27(22-45)32(21-30)41(42,43)44)11-13-34(26)57-18-17-49-15-16-50(25(2)23-49)24-36(54)47-29-8-6-7-28(20-29)46-33-12-14-35(53)48-37(33)55/h6-11,13,19-21,25,33,46H,5,12,14-18,23-24H2,1-4H3,(H,47,54)(H,48,53,55)/t25-,33?/m1/s1
InChiKey YUVGVJYLOFTILT-NHYGQJMQSA-N
CID 149429863
Short Description AR degrader

Related Products

AXON ID NAME FROM PRICE
4328 Hydroxyflutamide

From $132.00

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

Loading...