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BMS 309403
Axon 4277
CAS:
300657-03-8
Purity:
98%
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C31H26N2O3
- MW: 474.55
Description
Potent, selective and orally active adipocyte fatty acid binding protein (aFABP) inhibitor with Ki values of <2 nM for both mouse and human aP2 (FABP4), 250 nM for muscle FABP (FABP3) and 350 nM for mal1 (FABP5).
More Information
| Parent CAS No. | 300657-03-8 |
|---|---|
| Chemical Name | 2-(2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy)acetic acid |
| SMILES | C1=CC=C(C2=CC(OCC(=O)O)=CC=C2)C(N2N=C(C3=CC=CC=C3)C(C3=CC=CC=C3)=C2CC)=C1 |
| MFCD | MFCD09991687 |
| InChi | InChI=1S/C31H26N2O3/c1-2-27-30(22-12-5-3-6-13-22)31(23-14-7-4-8-15-23)32-33(27)28-19-10-9-18-26(28)24-16-11-17-25(20-24)36-21-29(34)35/h3-20H,2,21H2,1H3,(H,34,35) |
| InChiKey | SJRVJRYZAQYCEE-UHFFFAOYSA-N |
| CID | 16122583 |
| Short Description | aFABP inhibitor |
References
- R Sulsky et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5.
- M Furuhashi et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 2007 Jun 21;447(7147):959-65.
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