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PF-06281355
- PF1355
Axon 3992
CAS:
1435467-38-1
Purity:
99%
- Soluble in DMSO
- MF: C14H15N3O4S
- MW: 321.35
Description
PF-06281355 is a selective, orally active, mechanism-based myeloperoxidase (MPO) inhibitor, efficacious in cell assays and in vivo. Oral administration of PF-06281355 reduced plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction were completely suppressed by PF-06281355 treatment.
More Information
| Parent CAS No. | 1435467-38-1 |
|---|---|
| Chemical Name | 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide |
| SMILES | C1(C2N(CC(N)=O)C(=S)NC(=O)C=2)C(OC)=CC=C(OC)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22) |
| InChiKey | LJBUZOGABRDGBR-UHFFFAOYSA-N |
| CID | 71568997 |
| Short Description | MPO inhibitor |
