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LMTK3 inhibitor C28
Axon 3780
CAS:
2764850-23-7
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C18H11F3N4O
- MW: 356.3
Description
C28 is a potent LMTK3 inhibitor with an IC50 value of 67 nM. Pharmacologic inhibition of LMTK3 decreases proliferation of cancer cell lines in the NCI-60 panel, with a concomitant increase in apoptosis in breast cancer cells, recapitulating effects of LMTK3 gene silencing. Furthermore, LMTK3 inhibition reduces growth of xenograft and transgenic breast cancer mouse models without displaying systemic toxicity at effective doses.
More Information
| Parent CAS No. | 2764850-23-7 |
|---|---|
| Chemical Name | 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine |
| SMILES | C1C=C(C2C=CC3=NC=C(C4C=C(OC(F)(F)F)C=CC=4)N3N=2)C=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H11F3N4O/c19-18(20,21)26-14-3-1-2-13(10-14)16-11-23-17-5-4-15(24-25(16)17)12-6-8-22-9-7-12/h1-11H |
| InChiKey | SFBZOJORTROAIE-UHFFFAOYSA-N |
| CID | 138454301 |
| Short Description | LMTK3 inhibitor |
