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KCa modulator RA-2

Axon 3516
CAS:  1867107-62-7
Purity:  98%
  • Soluble in 0.1N NaOH(aq), DMSO and EtOH
  • MF:  C22H16F2O6
  • MW:  414.36

Description

RA-2 is a potent and selective KCa2/3 pan inhibitor with negative-gating modulator properties (IC50 values of 17 and 2 nM for KCa3.1 and KCa2.3, respectively). RA-2 inhibited EDH-type dilations in porcine coronary arteries (PCAs) and was found not to increase blood pressure in telemetry recordings despite reducing heart rate (HR).

More Information

Parent CAS No. 1867107-62-7
Chemical Name 1,3-Phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate)
SMILES C1C=C(C(=O)OCC2C=C(COC(=O)C3C=C(F)C(O)=CC=3)C=CC=2)C=C(F)C=1O
MFCD N.A.
InChi InChI=1S/C22H16F2O6/c23-17-9-15(4-6-19(17)25)21(27)29-11-13-2-1-3-14(8-13)12-30-22(28)16-5-7-20(26)18(24)10-16/h1-10,25-26H,11-12H2
InChiKey XOZKRECPKXTNAK-UHFFFAOYSA-N
CID 122173996
Short Description KCa2/3 inhibitor

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