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Senicapoc
- ICA-17043
Axon 3951
CAS:
289656-45-7
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C20H15F2NO
- MW: 323.34
Description
Senicapoc is a potent and selective antagonist of the Gardos (KCa3.1) channel with an IC50 value of 11 nM.
More Information
| Parent CAS No. | 289656-45-7 |
|---|---|
| Chemical Name | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide |
| SMILES | C1(C(C(N)=O)(C2C=CC(F)=CC=2)C2C=CC(F)=CC=2)C=CC=CC=1 |
| MFCD | MFCD09027349 |
| InChi | InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) |
| InChiKey | SCTZUZTYRMOMKT-UHFFFAOYSA-N |
| CID | 216327 |
| Short Description | Gardos channel antagonist |
References
- JW Stocker et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101(6):2412-8.
- GA McNaughton-Smith et al. Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82.
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