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(S)-VU0637120
Axon 3435
CAS:
1175940-86-9
- Optical Purity: 100% e.e.
- Soluble in DMSO and EtOH
- MF: C16H19N3O5S2
- MW: 397.47
Description
(S)-VU0637120 is a first-in-class, selective neuropeptide Y4 receptor allosteric antagonist with an IC50 value of 2.7 μM. (S)-VU0637120 selectively inhibits native Y4R function and binds in an allosteric site located below the binding pocket of the endogenous ligand pancreatic polypeptide in the core of the Y4R transmembrane domains.
More Information
| Parent CAS No. | 1175940-86-9 |
|---|---|
| Chemical Name | (2S)-N-(6,7-Dihydro[1,4]dioxino[2,3-f]benzothiazol-2-yl)-1-(methylsulfonyl)-2-piperidinecarboxamide |
| SMILES | C1OC2C=C3SC(NC(=O)[C@H]4N(S(=O)(=O)C)CCCC4)=NC3=CC=2OC1 |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H19N3O5S2/c1-26(21,22)19-5-3-2-4-11(19)15(20)18-16-17-10-8-12-13(9-14(10)25-16)24-7-6-23-12/h8-9,11H,2-7H2,1H3,(H,17,18,20)/t11-/m0/s1 |
| InChiKey | XLSQVBRMGFLMGL-NSHDSACASA-N |
| CID | 25881665 |
| Short Description | Y4R allosteric antagonist |
