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UTL-5g
- GBL-5g
Axon 3410
CAS:
646530-37-2
Purity:
99%
- Soluble in DMSO
- MF: C11H8Cl2N2O2
- MW: 271.1
Description
UTL-5g is a modulator of tumor necrosis factor-α (TNFα). UTL-5g shows potential chemoprotection against cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. Moreover, UTL-5g is potentially radioprotective against acute phase of radiation-induced liver injury.
More Information
| Parent CAS No. | 646530-37-2 |
|---|---|
| Chemical Name | N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide |
| SMILES | C1(Cl)C=C(Cl)C=CC=1NC(=O)C1=NOC(C)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H8Cl2N2O2/c1-6-4-10(15-17-6)11(16)14-9-3-2-7(12)5-8(9)13/h2-5H,1H3,(H,14,16) |
| InChiKey | ULPKSWAQDCJLMN-UHFFFAOYSA-N |
| CID | 17173847 |
| Short Description | TNFα modulator |
References
- J Shaw et al. The small-molecule TNF-alpha modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. J Exp Ther Oncol. 2011;9(2):129-37.
- J Shaw et al. Pretreatment with A Small-Molecule Tumor Necrosis Factor-Alpha (TNF-α) Inhibitor, UTL-5g, Reduced Radiation-Induced Acute Liver Toxicity in Mice. Am J Biomed Sci 2012;4(2): 123-131.
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