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CTPI-2
Axon 3358
CAS:
68003-38-3
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C13H9ClN2O6S
- MW: 356.74
Description
CTPI-2 is a specific inhibitor of the mitochondrial citrate carrier SLC25A1 with a Kd value of 3.5 µM.
More Information
| Parent CAS No. | 68003-38-3 |
|---|---|
| Chemical Name | 2-(4-Chloro-3-nitrophenylsulfonamido)benzoic acid |
| SMILES | C1C(C(=O)O)=C(NS(=O)(=O)C2C=C([N+]([O-])=O)C(Cl)=CC=2)C=CC=1 |
| MFCD | MFCD00129907 |
| InChi | InChI=1S/C13H9ClN2O6S/c14-10-6-5-8(7-12(10)16(19)20)23(21,22)15-11-4-2-1-3-9(11)13(17)18/h1-7,15H,(H,17,18) |
| InChiKey | NJTHPOSQGFJTDP-UHFFFAOYSA-N |
| CID | 106350 |
| Short Description | SLC25A1 inhibitor |
References
- M Tan et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020 Jul;27(7):2143-2157.
- HR Fernandez et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018 Jul;25(7):1239-1258.
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