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OATD-01

Axon 3353
CAS:  2088453-21-6
  • Optical Purity:  Optically pure
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
  • MF:  C19H27ClN6O
  • MW:  390.91

Description

OATD-01 is a first-in-class, highly potent and selective CHIT1 inhibitor with an IC50 value of 23 nM. OATD-01 shows both an excellent PK profile in multiple species and selectivity against a panel of other off-targets. Furthermore, antifibrotic properties of OATD-01 were confirmed in a pulmonary interstitial fibrosis model induced by bleomycin.

More Information

Parent CAS No. 2088453-21-6
Chemical Name 3-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
SMILES O1[C@@H](C)CN(C2CCN(C3N=C(N)NN=3)CC2)[C@@H](CC2C=CC(Cl)=CC=2)C1 |&1:1,17,r|
MFCD N.A.
InChi InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1
InChiKey STWVLEKJQQRGMO-GUYCJALGSA-N
CID 126642132
Short Description CHIT1 inhibitor

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