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SBI-183

Axon 3209
CAS:  625403-59-0
Purity:  99%
  • Soluble in DMSO and EtOH
  • MF:  C18H20N2O2
  • MW:  296.36

Description

SBI-183 is an orally active inhibitor of QSOX1 (Kd value of 20 μM), thereby suppressing the proliferative and invasive phenotype of two renal cancer cell lines (786-O and RCJ-41T2), a triple negative breast cancer (TNBC) cell line (MDA-MB-231), a lung adenocarcinoma cell line (A549), and a pancreatic ductal adenocarcinoma (MIA PaCa2). Moreover, SBI-183 inhibits tumor growth in two independent human xenograft mouse models of renal cell carcinoma.

More Information

Parent CAS No. 625403-59-0
Chemical Name 3-Methoxy-N-(4-(pyrrolidin-1-yl)phenyl)benzamide
SMILES C1(N2CCCC2)C=CC(NC(=O)C2C=CC=C(OC)C=2)=CC=1
MFCD N.A.
InChi InChI=1S/C18H20N2O2/c1-22-17-6-4-5-14(13-17)18(21)19-15-7-9-16(10-8-15)20-11-2-3-12-20/h4-10,13H,2-3,11-12H2,1H3,(H,19,21)
InChiKey ZZJGTLJERDOEQV-UHFFFAOYSA-N
CID 1121741
Short Description QSOX1 inhibitor

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