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ERAP1 inhibitor compound 3
Axon 3208
CAS:
865273-97-8
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C20H21F3N2O5S
- MW: 458.45
Description
ERAP1 inhibitor compound 3 allosterically activates endoplasmic reticulum aminopeptidase 1 (ERAP1) hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates (EC50 value of 0.4 μM). ERAP1 inhibitor compound 3 inhibits ERAP1’s activity in a cellular antigen processing assay with an IC50 value of 1.0 μM.
More Information
| Parent CAS No. | 865273-97-8 |
|---|---|
| Chemical Name | 4-Methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid |
| SMILES | C1(C(=O)O)C=CC(OC)=C(S(=O)(=O)NC2C=C(C(F)(F)F)C=CC=2N2CCCCC2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H21F3N2O5S/c1-30-17-8-5-13(19(26)27)11-18(17)31(28,29)24-15-12-14(20(21,22)23)6-7-16(15)25-9-3-2-4-10-25/h5-8,11-12,24H,2-4,9-10H2,1H3,(H,26,27) |
| InChiKey | NDYXAJZYGMHQDN-UHFFFAOYSA-N |
| CID | 4798291 |
| Short Description | ERAP1 inhibitor |
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