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AC1903
Axon 3026
CAS:
831234-13-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C19H17N3O
- MW: 303.36
Description
AC1903 is a selective inhibitor of TRPC5 with an IC50 value of 14.7 μM.
More Information
| Parent CAS No. | 831234-13-0 |
|---|---|
| Chemical Name | 1-Benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine |
| SMILES | C1C=C2N=C(NCC3=CC=CO3)N(CC3C=CC=CC=3)C2=CC=1 |
| MFCD | MFCD06609959 |
| InChi | InChI=1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21) |
| InChiKey | OECUWHDVQIITIS-UHFFFAOYSA-N |
| CID | 667146 |
| Short Description | TRPC5 blocker |
References
- Y Zhou et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 Dec 8;358(6368):1332-1336.
- SH Sharma et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159.
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