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(±)-trans-ML-SI3
Axon 4114
CAS:
2108567-79-7
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H31N3O3S
- MW: 429.58
Description
(±)-trans-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50 values of 3.1 and 28.5 µM, respectively) and an activator of TRPML2 (EC50 value of 3.3 µM.
More Information
| Parent CAS No. | 2108567-79-7 |
|---|---|
| Chemical Name | rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide |
| MFCD | N.A. |
| Short Description | TRPML1/3 inhibitor;TRPML2 activator |
References
- W Wang et al. Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1373-81.
- C Leser et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
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