Bulk Inquiry
BI 01383298
- Soluble in DMSO
- MF: C19H19Cl2FN2O3S
- MW: 445.34
Description
BI 01383298 is a potent and selective SLC13A5 inhibitor with apparent IC50 values of 56 nM in HEK cells overexpressing SLC13A5 and 24 nM in HepG2 cells expressing endogenous SLC13A5. BI 01383298 is more than 1000-fold selective over the closely related transporters SLC13A2 and SLC13A3, which share the physiological substrates citrate and succinate.
SLC13A5, also known as the sodium-dependent citrate transporter (NaCT), regulates cellular citrate uptake and plays an important role in energy metabolism, lipid biosynthesis, and metabolic homeostasis. BI 01383298 was developed as a selective chemical probe by the Structural Genomics Consortium (SGC) for investigating SLC13A5 biology and citrate transport mechanisms.
Key Features
- Potent SLC13A5 inhibitor
- IC50: 56 nM in SLC13A5-overexpressing HEK cells
- IC50: 24 nM in HepG2 cells expressing endogenous SLC13A5
- More than 1000-fold selective over SLC13A2 and SLC13A3
- Chemical probe developed by SGC
Applications
- SLC13A5 and citrate transporter research
- Cellular metabolism studies
- Citrate uptake and transport investigations
- Metabolic homeostasis research
- Chemical biology and target validation studies
More Information
| Parent CAS No. | 2227549-00-8 |
|---|---|
| Chemical Name | 1-(3,5-Dichlorophenylsulfonyl)-N-(4-fluorobenzyl)piperidine-4-carboxamide |
| SMILES | N1(S(=O)(=O)C2C=C(Cl)C=C(Cl)C=2)CCC(C(NCC2C=CC(F)=CC=2)=O)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19Cl2FN2O3S/c20-15-9-16(21)11-18(10-15)28(26,27)24-7-5-14(6-8-24)19(25)23-12-13-1-3-17(22)4-2-13/h1-4,9-11,14H,5-8,12H2,(H,23,25) |
| InChiKey | VUOYAALVGSMUHC-UHFFFAOYSA-N |
| CID | 134604213 |
| Short Description | SLC13A5 inhibitor |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.