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STX64
- BN83495 - Irosustat - 667 Coumate
Axon 2892
CAS:
288628-05-7
Purity:
99%
- Soluble in DMSO
- MF: C14H15NO5S
- MW: 309.34
Description
Potent steroid sulfatase (STS) inhibitor with an IC50 value of 8 nM. First STS inhibitor to enter diverse clinical trials for patients with advanced hormone-dependent cancer.
More Information
| Parent CAS No. | 288628-05-7 |
|---|---|
| Chemical Name | 6-Oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate |
| SMILES | C1C=C2C3CCCCCC=3C(=O)OC2=CC=1OS(N)(=O)=O |
| MFCD | MFCD12912443 |
| InChi | InChI=1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18) |
| InChiKey | DSLPMJSGSBLWRE-UHFFFAOYSA-N |
| CID | 5287541 |
| Short Description | STS inhibitor |
References
- A Purohit et al. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 2000 Jul 1;60(13):3394-6.
- LW Woo et al. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495). ChemMedChem. 2011 Nov 4;6(11):2019-34.
