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AZD7986
- Brensocatib
Axon 2766
CAS:
1802148-05-5
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C23H24N4O4
- MW: 420.46
Description
AZD7986 is a highly potent, reversible, and selective DPP1 inhibitor (pIC50 value of 8.4). Moreover, good species crossover was seen with the DPP1 enzyme (pIC50 values of 7.6, 7.7, 7.8 and 7.8 for mouse, rat, dog and rabbit, respectively). Clinical candidate for COPD.
More Information
| Parent CAS No. | 1802148-05-5 |
|---|---|
| Chemical Name | (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide |
| SMILES | C1(C2C=CC(C[C@@H](C#N)NC(=O)[C@@H]3CNCCCO3)=CC=2)C=C2N(C)C(=O)OC2=CC=1 |&1:6,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 |
| InChiKey | AEXFXNFMSAAELR-RXVVDRJESA-N |
| CID | 118253852 |
| Short Description | DPP1 inhibitor |
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