Bulk Inquiry
EN460
- ERO1 Inhibitor II
Axon 2737
CAS:
496807-64-8
Purity:
99%
- Soluble in DMSO
- MF: C22H12ClF3N2O4
- MW: 460.79
Description
EN460, an inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50 value of 1.9 μM). Despite rapid and promiscuous reactivity with thiolates, EN460 exhibits selectivity for ERO1.
More Information
| Parent CAS No. | 496807-64-8 |
|---|---|
| Chemical Name | (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid |
| SMILES | C1C(N2N=C(C(F)(F)F)/C(=C/C3=CC=C(C4C=CC=CC=4)O3)/C2=O)=CC=C(Cl)C=1C(O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C22H12ClF3N2O4/c23-17-8-6-13(10-15(17)21(30)31)28-20(29)16(19(27-28)22(24,25)26)11-14-7-9-18(32-14)12-4-2-1-3-5-12/h1-11H,(H,30,31)/b16-11- |
| InChiKey | RSLFQCNAOMQAIH-WJDWOHSUSA-N |
| CID | 1016023 |
| Short Description | ERO1 inhibitor |
