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STAT5 Inhibitor 1 [285986-31-4]
Axon 2731
CAS:
285986-31-4
Purity:
98%
- Soluble in DMSO
- MF: C16H11N3O3
- MW: 293.28
Description
STAT5 Inhibitor 1 [285986-31-4] is a first nonpeptidic small-molecule which selectively inhibits the function of the STAT5b domain (IC50 value of 47 μM), STAT5 DNA binding in vitro, and activation of STAT5 in a cancer cell line. Also selective impairment of STAT5 phosphorylation with STAT5 Inhibitor 1 markedly reduced iTregs.
More Information
| Parent CAS No. | 285986-31-4 |
|---|---|
| Chemical Name | N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide |
| SMILES | C1N=CC(C(=O)N/N=C/C2C(=O)C3C=CC=CC=3OC=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)/b18-9+ |
| InChiKey | DAVIKTBRCQWOGT-GIJQJNRQSA-N |
| CID | 9566174 |
| Short Description | STAT5 inhibitor |
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