2025

Parviainen, T. A., Duong, M. T. H., Pääkkönen, J., Burdova, K., Kuttichova, B., Hanzlikova, H., ... & Heiskanen, J. P. (2025). Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3. ACS Chemical Biology.
https://pubs.acs.org/doi/abs/10.1021/acschembio.5c00461

Ferrand, J., Dabin, J., Chevallier, O., Kane-Charvin, M., Kupai, A., Hrit, J., ... & Polo, S. E. (2025). Mitotic chromatin marking governs the segregation of DNA damage. Nature Communications, 16(1), 746.
https://www.nature.com/articles/s41467-025-56090-8

2024

Ferrand, J., Dabin, J., Chevallier, O., Kane-Charvin, M., Kupai, A., Hrit, J., ... & Polo, S. E. (2024). Mitotic chromatin marking governs asymmetric segregation of DNA damage. BioRxiv, 2023-09.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10508772/

Bilkis, R. (2024). Functional Analysis of Chromatin Remodeler CSB in PARP1/2-Mediated Oxidative DNA Lesion Repair (Doctoral dissertation, The University of New Mexico).
https://www.proquest.com/openview/0cb87292b575efefd22a17bfd3e89dd3/1?pq-origsite=gscholar&cbl=18750&diss=y

Vermeulen, W., & Lans, H., Davó-Martínez, C., Helfricht, A., Ribeiro-Silva, C., Raams, A., Tresini, M., Uruci, S., van Cappellen, W. A., Taneja, N., Demmers, J. A. A., Pines, A., & Theil, A. F. (2024). Real-time methods and mechanisms, 35.
https://pure.eur.nl/ws/portalfiles/portal/170493004/cdavoembargo_-_6713f7f14f72e.pdf#page=38

2023

Gautam, A., Fawcett, H., Burdova, K., Brazina, J., & Caldecott, K. W. (2023). APE1-dependent base excision repair of DNA photodimers in human cells. Molecular Cell, 83(20), 3669-3678.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00735-9

Bilkis, R., Lake, R. J., Cooper, K. L., Tomkinson, A., & Fan, H. Y. (2023). The CSB chromatin remodeler regulates PARP1-and PARP2-mediated single-strand break repair at actively transcribed DNA regions. Nucleic Acids Research, 51(14), 7342-7356.
https://academic.oup.com/nar/article/51/14/7342/7199336

Kuttichová, B. (2023). ADP-ribosylation in ARH3-deficient cells and its impact on cellular functions.
https://dspace.cuni.cz/bitstream/handle/20.500.11956/185708/120458976.pdf?sequence=1&isAllowed=y

2022

Van, H., & Van, H. T. (2022). Plant Homeodomain Finger Protein 20 (Phf20) And Its Homolog Phf20 Like 1 (Phf20L1) Define Two Distinct Non-Specific Lethal (Nsl) Complexes.
https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=2216&context=utgsbs_dissertations

Huiting, W., Dekker, S. L., van der Lienden, J. C., Mergener, R., Musskopf, M. K., Furtado, G. V., ... & Bergink, S. (2022). Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. Elife, 11, e70726.
https://elifesciences.org/articles/70726.pdf
* KU-0058594, VE821, and VER15508 from Axon Medchem

Vaitsiankova, A., Burdova, K., Sobol, M., Gautam, A., Benada, O., Hanzlikova, H., & Caldecott, K. W. (2022). PARP inhibition impedes the maturation of nascent DNA strands during DNA replication. Nature Structural & Molecular Biology, 29(4), 329-338.
https://www.nature.com/articles/s41594-022-00747-1
* KU0058948 and JH-RE-06 from Axon Medchem

2021

Demin, A. A., Hirota, K., Tsuda, M., Adamowicz, M., Hailstone, R., Brazina, J., ... & Caldecott, K. W. (2021). XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Molecular Cell, 81(14), 3018-3030.
https://www.sciencedirect.com/science/article/pii/S109727652100366X

Komulainen, E., Badman, J., Rey, S., Rulten, S., Ju, L., Fennell, K., ... & Caldecott, K. W. (2021). Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. EMBO Reports, 22(5), e51851.
https://www.embopress.org/doi/full/10.15252/embr.202051851

Breuer, G. A., Bezney, J., Fons, N. R., Sundaram, R. K., Feng, W., Gupta, G. P., & Bindra, R. S. (2021). CRISPR screening identifies novel PARP inhibitor classification based on distinct base excision repair pathway dependencies. bioRxiv, 2020-10.
https://www.biorxiv.org/content/10.1101/2020.10.18.333070v2.full
* KU0058948 and AG-014669 from Axon Medchem

Adamowicz, M., Hailstone, R., Demin, A. A., Komulainen, E., Hanzlikova, H., Brazina, J., ... & Caldecott, K. W. (2021). XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nature Cell Biology, 23(12), 1287-1298.
https://www.nature.com/articles/s41556-021-00792-w

2020

Breuer, G. A., Bezney, J., Fons, N. R., Sundaram, R. K., Feng, W., Gupta, G. P., & Bindra, R. S. (2020). Targeted DNA Damage Repair CRISPR/Cas9 Knockout Screen Identifies Novel Classification of Poly-ADP Ribose Polymerase Inhibitors Based on Key Base Excision Repair Proteins. bioRxiv.
https://web.archive.org/web/20201210000717id_/https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.18.333070.full.pdf

Hanzlikova, H., Prokhorova, E., Krejcikova, K., Cihlarova, Z., Kalasova, I., Kubovciak, J., ... & Caldecott, K. W. (2020). Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature Communications, 11(1), 1-13.
https://www.nature.com/articles/s41467-020-17069-9

2019

Martinez-Macias, M. I., Moore, D. A., Green, R. L., Gomez-Herreros, F., Naumann, M., Hermann, A., ... & Caldecott, K. W. (2019). FUS is part of the cellular response to topoisomerase-induced DNA breaks and transcriptional stress. Life Science Alliance.
http://sro.sussex.ac.uk/id/eprint/81954/

Martinez-Macias, M. I., Moore, D. A., Green, R. L., Gomez-Herreros, F., Naumann, M., Hermann, A., ... & Caldecott, K. W. (2019). FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress. Life Science Alliance, 2(2).
https://www.life-science-alliance.org/content/2/2/e201800222.abstract

Nie, Y., Li, Y., Li, X., Wilson, A. F., & Pang, Q. (2019). The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance. Stem Cell Research & Therapy, 10(1), 114.
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1206-0

Mesman, R. L., Calleja, F. M., Hendriks, G., Morolli, B., Misovic, B., Devilee, P., ... & Vreeswijk, M. P. (2019). The functional impact of variants of uncertain significance in BRCA2. Genetics in Medicine, 21(2), 293-302.
https://www.nature.com/articles/s41436-018-0052-2/

Wijenberg, L. (2019). PARP inhibitor resistance in BRCA1/2 mutated tumors (RuG Doctoral dissertation).
http://fse.studenttheses.ub.rug.nl/21252/1/mBMS_2019_WijenbergL.pdf

2018

Boetefuer, E. L., Lake, R. J., Dreval, K., & Fan, H. Y. (2018). Poly (ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress–induced association of Cockayne syndrome group B protein with chromatin. Journal of Biological Chemistry, 293(46), 17863-17874.
https://www.jbc.org/content/293/46/17863.full

Boetefuer, E. L. (2018). Mechanisms Underlying Oxidative Stress-Induced Chromatin Association Of Cockayne Syndrome Protein B (csb). UPENN PhD Dissertation.
https://repository.upenn.edu/edissertations/2766/

Nagle, P. W., Hosper, N. A., Barazzuol, L., Jellema, A. L., Baanstra, M., van Goethem, M. J., ... & Coppes, R. P. (2018). Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction. Clinical Cancer Research.
http://clincancerres.aacrjournals.org/content/early/2018/08/22/1078-0432.CCR-18-0533.abstract
* KU-55933 and KU-0058948 from Axon Medchem

Mesman, R. L., Calleja, F. M., Hendriks, G., Morolli, B., Misovic, B., Devilee, P., ... & Vreeswijk, M. P. (2018). The functional impact of variants of uncertain significance in BRCA2. Genetics in Medicine.
https://www.nature.com/articles/s41436-018-0052-2