List of publications using AZD6244 - Selumetinib (Axon 1516) purchased from Axon Medchem
(Total 13 publication citations listed; incomplete list up to April 2020)
Marqués, M., Tranchant, R., Risa-Ebrí, B., Suárez-Solís, M. L., Fernández, L. C., Carrillo-de-Santa-Pau, E., ... & Blum, Y. (2020). Combined MEK and PI3K/p110b inhibition as a novel targeted therapy for malignant mesothelioma displaying sarcomatoid features. Cancer Research.
https://cancerres.aacrjournals.org/content/early/2020/01/04/0008-5472.CAN-19-1633.short
* Selumetinib, PD0325901 from Axon Medchem
* Selumetinib, PD0325901 from Axon Medchem
Stutvoet, T. S., Kol, A., de Vries, E. G., de Bruyn, M., Fehrmann, R. S., Terwisscha van Scheltinga, A. G., & de Jong, S. (2019). MAPK pathway activity plays a key role in PD‐L1 expression of lung adenocarcinoma cells. The Journal of pathology, 249(1), 52-64.
Caumanns, J. J., van Wijngaarden, A., Kol, A., Meersma, G. J., Jalving, M., Bernards, R., ... & de Jong, S. (2019). Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma. Cancer letters, 461, 102-111.
https://www.sciencedirect.com/science/article/pii/S0304383519304008
*AZD8055, GDC0941, Selumetinib and MLN0128 from Axon Medchem
de Boer, H. R., Pool, M., Joosten, E., Everts, M., Samplonius, D. F., Helfrich, W., ... & de Vries, E. G. (2019). Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition. Oncogene, 38(9), 1477-1488.
https://d-nb.info/1171695896/34
https://www.nature.com/articles/s41388-018-0522-7
* Erlotinib, Gefitinib, and AZD6244 from Axon Medchem
https://www.sciencedirect.com/science/article/pii/S0304383519304008
*AZD8055, GDC0941, Selumetinib and MLN0128 from Axon Medchem
de Boer, H. R., Pool, M., Joosten, E., Everts, M., Samplonius, D. F., Helfrich, W., ... & de Vries, E. G. (2019). Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition. Oncogene, 38(9), 1477-1488.
https://d-nb.info/1171695896/34
https://www.nature.com/articles/s41388-018-0522-7
* Erlotinib, Gefitinib, and AZD6244 from Axon Medchem
Furlan, T., Khalid, S., Nguyen, A. V., Günther, J., & Troppmair, J. (2018). The oxidoreductase p66Shc acts as tumor suppressor in BRAFV 600E‐transformed cells. Molecular oncology, 12(6), 869-882.
https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12199
Sagiv, A., Burton, D. G., Moshayev, Z., Vadai, E., Wensveen, F., Ben-Dor, S., ... & Krizhanovsky, V. (2016). NKG2D ligands mediate immunosurveillance of senescent cells. Aging (Albany NY), 8(2), 328.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789586/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789586/
Bosma, N. A., Singla, A. K., Downey, C. M., & Jirik, F. R. (2014). Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice. Oncoscience, 1(12), 821.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303890/
Costales, A.Q., Huang, S., Jin, J.X., Liu, Z., Pecchi, S., Poon, D., Tellew, J. and Zhang, Q., Novartis AG, 2014. Compounds and compositions as protein kinase inhibitors. U.S. Patent 8,859,548.
https://patents.google.com/patent/US8859548/en
* PD-0325901, PD-184352, SL-032, LY294002, PI-103, PIK75, PIK90, GDC0941, BEZ235, AS252424, TGX-221 and AZD6244 from Axon Medchem
Costales, A.Q., Huang, S., Jin, J.X., Liu, Z., Pecchi, S., Poon, D. and Tellew, J., IRM LLC and Novartis AG, 2013. Compounds and compositions as protein kinase inhibitors. U.S. Patent 8,563,553.
https://patents.google.com/patent/US8563553B2/en
https://patents.google.com/patent/US8242260B2/en
* PD-0325901, PD-184352, SL-032, LY294002, PI-103, PIK75, PIK90, GDC0941, BEZ235, AS252424, TGX-221 and AZD6244 from Axon Medchem
Madera, A.M., Poon, D. and Smith, A., Novartis AG, 2013. Heteroaryl compounds and compositions as protein kinase inhibitors. U.S. Patent Application 13/805,793.
https://patents.google.com/patent/US20130096149A1/en
* PD0325901, PD184352, Sl327, LY294002, PI-103, PIK75, PIK90, GDC0941, AS-252424, TGX221, AZD6244 from Axon Medchem
Costales, A.Q., Huang, S., Jin, J.X., Liu, Z., Pecchi, S., Poon, D., Tellew, J. and Zhang, Q., Novartis AG, 2012. Compounds and compositions as protein kinase inhibitors. U.S. Patent 8,242,260.
https://patents.google.com/patent/US8242260B2/en
* PD-0325901, PD-184352, SL-032, LY294002, PI-103, PIK75, PIK90, GDC0941, BEZ235, AS252424, TGX-221 and AZD6244 from Axon Medchem
https://patents.google.com/patent/US8242260B2/en
* PD-0325901, PD-184352, SL-032, LY294002, PI-103, PIK75, PIK90, GDC0941, BEZ235, AS252424, TGX-221 and AZD6244 from Axon Medchem
Weigelt, B., Warne, P. H., & Downward, J. (2011). PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene, 30(29), 3222-3233.
https://www.nature.com/articles/onc201142
Burkhard, K., & Shapiro, P. (2010). Use of inhibitors in the study of MAP kinases. In MAP Kinase Signaling Protocols (pp. 107-122). Humana Press, Totowa, NJ.https://www.nature.com/articles/onc201142
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727897/
* Erlotinib, Sunitinib, Sorafenib, Dasatinib, Imatinib, PD184352, SB203580, SB202190, BIRB796 from Axon Medchem