List of publications utilizing BX 912 (Axon 1130) purchased from Axon Medchem 

(Total 16 publication citations listed; updated JUNE-2016)

2015
Tsuchiya, A., Kanno, T., Shimizu, T., Tanaka, A. and Nishizaki, T., 2015. Rac1 and ROCK are implicated in the cell surface delivery of GLUT4 under the control of the insulin signal mimetic diDCP-LA-PE. Journal of pharmacological sciences, 128(4), pp.179-184.

http://www.sciencedirect.com/science/article/pii/S1347861315001218  

D’Alessandro, L.A., Samaga, R., Maiwald, T., Rho, S.H., Bonefas, S., Raue, A., Iwamoto, N., Kienast, A., Waldow, K., Meyer, R. and Schilling, M., 2015. Disentangling the complexity of HGF signaling by combining qualitative and quantitative modeling. PLoS Comput Biol, 11(4), p.e1004192.
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004192 
 
Keifer, J. and Zheng, Z., 2015. Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3‐phosphoinositide‐dependent kinase‐1 signalling and modulated by adenosine receptors. The Journal of physiology, 593(7), pp.1581-1595.
http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.282947/full 
 
2014
Bhatnagar, S., Zhu, X., Ou, J., Lin, L., Chamberlain, L., Zhu, L.J., Wajapeyee, N. and Green, M.R., 2014. Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proceedings of the National Academy of Sciences, 111(35), pp.12591-12598.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156765/ 
 
Kravtsov, D., Mashukova, A., Forteza, R., Rodriguez, M.M., Ameen, N.A. and Salas, P.J., 2014. Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. American Journal of Physiology-Gastrointestinal and Liver Physiology, 307(10), pp.G992-G1001.
http://ajpgi.physiology.org/content/307/10/G992.full

2013
PDK1 decreases TACE-mediated [alpha]-secretase activity and promotes disease progression in prion and Alzheimer's diseases. 
Pietri, M., Dakowski, C., Hannaoui, S., Alleaume-Butaux, A., Hernandez-Rapp, J., Ragagnin, A., ... & Schneider, B. 
Nat Med. 2013 Sep;19(9):1124-31. doi: 10.1038/nm.3302.

PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ZN Wee, YC Lim, RKM Karuturi and Q Yu.
Cancer Discov. 2013 Oct;3(10):1156-71. doi: 10.1158/2159-8290.CD-12-0595.
... 60 inhibitors including BX912 were purchased from Axon Medchem

Endoplasmic reticulum-associated ubiquitin conjugating enzyme-Ube2j1 is a novel substrate of MAPKAP kinase-2 involved in MK2-mediated TNFalpha production. 
MB Menon, C Tiedje, J Lafera, N Ronkina, T Konen, A Kotlyarov and M Gaestel.
Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755.
(* SB202190, BX912 and BIRB796 from Axon)
 
Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453.
SB Sato, J Park, J Kawamoto, S Sato, T Kurihara.
Biochim. Biophys. Acta (BBA) - Mol. Cell Biol. Lipids. 2013, 1831 (2), 306-313.
 
METHODS AND COMPOSITIONS FOR TREATING CANCER
Q Yu, J Tan
US Patent 20,130,123,328, 2013.

Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. 
CR McNamara, R Ahuja, AD Osafo-Addo, D Barrows, A Kettenbach, I Skidan, ... & A Degterev. 
PloS one, 2013, 8(3), e56576.
 

2012
An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes.
J Huard, S Mueller, ED Gilles, U Klingmüller, S Klamt.
FEBS J. 2012, 279 (18), 3290–3313. DOI: 10.1111/j.1742-4658.2012.08572.x

PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.
A Mashukova, R Forteza, FA Wald, PJ Salas.
Mol. Biol. Cell. 2012, 23 (9), 1664-1674. doi: 10.1091/mbc.E11-12-0988

2011
Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells.
B Kloo, D Nagel, M Pfeifer, M Grau, M Düwel, M Vincendeau, B Dörken, P Lenz, G Lenz, D Krappmann.
PNAS USA 2011, 108 (1), 272-277.  doi: 10.1073/pnas.1008969108 

2010
B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer.
J Tan, PL Lee, Z Li, X Jiang, YC Lim, SC Hooi, Q Yu.
Cancer Cell. 2010, 18 (5), 459–471.
 

2009
Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells.
AF Fernandes, Q Bian, JK Jiang, CJ Thomas, A Taylor, P Pereira, F Shang.
Mol. Biol. Cell, 2009, 20 (16), 3690-3699.  doi: 10.1091/mbc.E08-10-1068 

(This is an incomplete list, updated in JUNE 2016)

 

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