List of publications utilizing BX 912 (Axon 1130) purchased from Axon Medchem 

(Total 16 publication citations listed; updated JUNE-2016)

Tsuchiya, A., Kanno, T., Shimizu, T., Tanaka, A. and Nishizaki, T., 2015. Rac1 and ROCK are implicated in the cell surface delivery of GLUT4 under the control of the insulin signal mimetic diDCP-LA-PE. Journal of pharmacological sciences, 128(4), pp.179-184.  

D’Alessandro, L.A., Samaga, R., Maiwald, T., Rho, S.H., Bonefas, S., Raue, A., Iwamoto, N., Kienast, A., Waldow, K., Meyer, R. and Schilling, M., 2015. Disentangling the complexity of HGF signaling by combining qualitative and quantitative modeling. PLoS Comput Biol, 11(4), p.e1004192. 
Keifer, J. and Zheng, Z., 2015. Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3‐phosphoinositide‐dependent kinase‐1 signalling and modulated by adenosine receptors. The Journal of physiology, 593(7), pp.1581-1595. 
Bhatnagar, S., Zhu, X., Ou, J., Lin, L., Chamberlain, L., Zhu, L.J., Wajapeyee, N. and Green, M.R., 2014. Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proceedings of the National Academy of Sciences, 111(35), pp.12591-12598. 
Kravtsov, D., Mashukova, A., Forteza, R., Rodriguez, M.M., Ameen, N.A. and Salas, P.J., 2014. Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. American Journal of Physiology-Gastrointestinal and Liver Physiology, 307(10), pp.G992-G1001.

PDK1 decreases TACE-mediated [alpha]-secretase activity and promotes disease progression in prion and Alzheimer's diseases. 
Pietri, M., Dakowski, C., Hannaoui, S., Alleaume-Butaux, A., Hernandez-Rapp, J., Ragagnin, A., ... & Schneider, B. 
Nat Med. 2013 Sep;19(9):1124-31. doi: 10.1038/nm.3302.

PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ZN Wee, YC Lim, RKM Karuturi and Q Yu.
Cancer Discov. 2013 Oct;3(10):1156-71. doi: 10.1158/2159-8290.CD-12-0595.
... 60 inhibitors including BX912 were purchased from Axon Medchem

Endoplasmic reticulum-associated ubiquitin conjugating enzyme-Ube2j1 is a novel substrate of MAPKAP kinase-2 involved in MK2-mediated TNFalpha production. 
MB Menon, C Tiedje, J Lafera, N Ronkina, T Konen, A Kotlyarov and M Gaestel.
Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755.
(* SB202190, BX912 and BIRB796 from Axon)
Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453.
SB Sato, J Park, J Kawamoto, S Sato, T Kurihara.
Biochim. Biophys. Acta (BBA) - Mol. Cell Biol. Lipids. 2013, 1831 (2), 306-313.
Q Yu, J Tan
US Patent 20,130,123,328, 2013.

Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. 
CR McNamara, R Ahuja, AD Osafo-Addo, D Barrows, A Kettenbach, I Skidan, ... & A Degterev. 
PloS one, 2013, 8(3), e56576.

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes.
J Huard, S Mueller, ED Gilles, U Klingmüller, S Klamt.
FEBS J. 2012, 279 (18), 3290–3313. DOI: 10.1111/j.1742-4658.2012.08572.x

PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.
A Mashukova, R Forteza, FA Wald, PJ Salas.
Mol. Biol. Cell. 2012, 23 (9), 1664-1674. doi: 10.1091/mbc.E11-12-0988

Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells.
B Kloo, D Nagel, M Pfeifer, M Grau, M Düwel, M Vincendeau, B Dörken, P Lenz, G Lenz, D Krappmann.
PNAS USA 2011, 108 (1), 272-277.  doi: 10.1073/pnas.1008969108 

B55β-Associated PP2A Complex Controls PDK1-Directed Myc Signaling and Modulates Rapamycin Sensitivity in Colorectal Cancer.
J Tan, PL Lee, Z Li, X Jiang, YC Lim, SC Hooi, Q Yu.
Cancer Cell. 2010, 18 (5), 459–471.

Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells.
AF Fernandes, Q Bian, JK Jiang, CJ Thomas, A Taylor, P Pereira, F Shang.
Mol. Biol. Cell, 2009, 20 (16), 3690-3699.  doi: 10.1091/mbc.E08-10-1068 

(This is an incomplete list, updated in JUNE 2016)


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