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HDL376
Axon 4335
CAS:
147751-31-3
Purity:
100%
- Soluble in DMSO and EtOH
- MF: C12H17ClN2S
- MW: 256.8
Description
HDL376 is a potent and orally active scavenger receptor class B type I (SR-BI) inhibitor. Moreover, HDL376 is a potent blocker of lipid transport (BLT) in cultured cells, inhibiting SR-BI-mediated lipid transport with an IC50 of ~1 mM.
More Information
| Parent CAS No. | 147751-31-3 |
|---|---|
| Chemical Name | 1-(5-Chloro-2-tolyl)-3-isobutylthiourea |
| SMILES | C1(Cl)=CC(NC(=S)NCC(C)C)=C(C)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C12H17ClN2S/c1-8(2)7-14-12(16)15-11-6-10(13)5-4-9(11)3/h4-6,8H,7H2,1-3H3,(H2,14,15,16) |
| InChiKey | CVLONJGXRCEARL-UHFFFAOYSA-N |
| CID | 3033829 |
| Short Description | SR-BI inhibitor |
References
- GM Coppola et al. Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorg Med Chem Lett. 2006 Jan 1;16(1):113-7.
- TJ Nieland et al. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48(8):1832-45.
