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NMD670
Axon 4194
CAS:
2354321-33-6
- Optical Purity: 99% e.e.
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C12H10BrNO4
- MW: 312.12
Description
NMD670 is a first-in-class orally bioavailable inhibitor of skeletal muscle-specific chloride channel ClC-1. NMD670 augmented muscle excitability in response to motor commands and thereby improved muscle function in rat models of Myasthenia gravis.
More Information
| Parent CAS No. | 2354321-33-6 |
|---|---|
| Chemical Name | (S)-2-[4-Bromo-2-(3-isoxazolyl)phenoxy]propionic acid |
| SMILES | C1(C2C=CON=2)C(O[C@@H](C)C(=O)O)=CC=C(Br)C=1 |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C12H10BrNO4/c1-7(12(15)16)18-11-3-2-8(13)6-9(11)10-4-5-17-14-10/h2-7H,1H3,(H,15,16)/t7-/m0/s1 |
| InChiKey | XKXLEZCOELWNMB-ZETCQYMHSA-N |
| CID | 138684045 |
| Short Description | ClC-1 inhibitor |
References
- M Skov et al. The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Sci Transl Med. 2024 Mar 20;16(739):eadk9109.
- TQ Ruijs et al. Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial. Clin Pharmacol Ther. 2025 Mar;117(3):768-778.
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