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OTUB2-IN-1

Axon 4174
CAS:  300558-22-9
Purity:  98%
  • Soluble in 0.1N NaOH(aq) and DMSO
  • MF:  C19H18N2O6S2
  • MW:  434.49

Description

OTUB2-IN-1 is a specific inhibitor of OTUB2 (Kd value of 12 µM), which can reduce the expression of PD-L1 proteins in tumor cells and suppress tumor growth by promoting robust intra-tumoral infiltration of cytotoxic T lymphocytes.

More Information

Parent CAS No. 300558-22-9
Chemical Name 6-(5-(1-(Carboxymethyl)-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid
SMILES C(N1C(=O)/C(=C2C(=O)N(CC(=O)O)C3C=CC=CC2=3)/SC1=S)CCCCC(=O)O
MFCD N.A.
InChi InChI=1S/C19H18N2O6S2/c22-13(23)8-2-1-5-9-20-18(27)16(29-19(20)28)15-11-6-3-4-7-12(11)21(17(15)26)10-14(24)25/h3-4,6-7H,1-2,5,8-10H2,(H,22,23)(H,24,25)/b16-15+
InChiKey VQTUGMPRAUNMNP-FOCLMDBBSA-N
CID 2139805
Short Description OTUB2 inhibitor

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Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

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