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RS504393

Name: RS504393
SKU: 4167

Axon 4167

CAS: 300816-15-3

Purity: 99%

Soluble in DMSO and EtOH

MF: C25H27N3O3
MW: 417.5

Description

RS504393 is a selective CCR2 antagonist with an IC50 value of 89 nM. Moreover, RS504393 blocks MCP-1 and MCP-3 signaling through CCR2.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Chemokine

Parent CAS No.	300816-15-3
Chemical Name	6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
MFCD	MFCD09038564
Short Description	CCR2 antagonist

RS504393 CCR2 antagonist RS 504393 RS-504393 CAS 300816-15-3 Axon Medchem Axon 4167 Chemokine Antagonist Receptors Rheumatoid arthritis Inflammatory disease MCP-1 Supplier Vendor

References

T Mirzadegan et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.

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RS504393

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