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IGGi-11me
- IGGi-11 prodrug
Axon 4160
CAS:
N.A.
Purity:
98%
- Soluble in DMSO
- MF: C25H32N2O8S2
- MW: 552.66
Description
IGGi-11me is a membrane permeable prodrug of IGGi-11, which is the first-in-class inhibitor of noncanonical activation of heterotrimeric G-protein signaling. IGGi-11 binding to G-protein α-subunits (Gαi) specifically disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer cells.
The membrane permeability of IGGi-11me was higher than that of IGGi-11. The esterase in the cytoplasm of MDA-MB-231 cells could convert IGGi-11me into IGGi-11. Thus, IGGi-11me acts as a prodrug, allowing IGGi-11 to function in cells much better.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | Dimethyl 4,4'-((9H-fluorene-2,7-disulfonyl)bis(methylazanediyl))dibutyrate |
| MFCD | N.A. |
| Short Description | GIV-Gαi inhibitor |
