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Voxelotor
- GBT440
Axon 4088
CAS:
1446321-46-5
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C19H19N3O3
- MW: 337.37
Description
Voxelotor is a first-in-class, potent and orally bioavailable allosteric effector of sickle cell hemoglobin (HbS). Voxelotor increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
More Information
| Parent CAS No. | 1446321-46-5 |
|---|---|
| Chemical Name | 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| SMILES | N1C=CC=C(COC2C(C=O)=C(O)C=CC=2)C=1C1=CC=NN1C(C)C |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3 |
| InChiKey | FWCVZAQENIZVMY-UHFFFAOYSA-N |
| CID | 71602803 |
| Short Description | HbS effector |
References
- B Metcalf et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.
- JH Estepp. Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data. Am J Hematol. 2018 Mar;93(3):326-329.
