Bulk Inquiry
Dyngo-4a
- Hydroxy-dynasore
Axon 4029
CAS:
1256493-34-1
Purity:
99%
- Soluble in DMSO
- MF: C18H14N2O5
- MW: 338.31
Description
Hydroxy-Dynasore is a cell-permeable dynamin and endocytosis inhibitor. Hydroxy-Dynasore inhibits dynamin I and II with IC50 values of 0.38 µM and 2.3 µM, respectively. Also, Hydroxy-Dynasore is a potent MUS81-EME1/2 inhibitor.
More Information
| Parent CAS No. | 1256493-34-1 |
|---|---|
| Chemical Name | 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide |
| SMILES | C1C=C2C=C(C(=O)N/N=C/C3C=C(O)C(O)=CC=3O)C(O)=CC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+ |
| InChiKey | UAXHPUSKEWEOAP-DJKKODMXSA-N |
| CID | 136227923 |
| Short Description | Dynamin inhibitor |
References
- A McCluskey et al. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic. 2013 Dec;14(12):1272-89.
- X Zhang et al. Identification of small-molecule inhibitors of human MUS81-EME1/2 by FRET-based high-throughput screening. Bioorg Med Chem. 2023 Jul 15;90:117383.
Other Categories
Get a Quote for
Loading...