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NUC-1031

 - Acelarin
Axon 3858
CAS:  840506-29-8
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C25H27F2N4O8P
  • MW:  580.47

Description

NUC-1031 is a phosphoramidate ProTide, and a pro-drug of anticancer nucleoside analog Gemcitabine (Axon 3233). NUC-1031 is a first-in-class nucleotide analogue using phosphoramidate chemistry to enhance anti-cancer efficacy.

More Information

Parent CAS No. 840506-29-8
Chemical Name (2S)-Benzyl 2-((((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
extra_info Sold in collaboration with Chemietek
SMILES C1(=O)N=C(N)C=CN1[C@@H]1O[C@H](COP(N[C@@H](C)C(OCC2C=CC=CC=2)=O)(OC2C=CC=CC=2)=O)[C@@H](O)C1(F)F |&1:8,10,15,35,r|
MFCD N.A.
InChi InChI=1S/C25H27F2N4O8P/c1-16(22(33)36-14-17-8-4-2-5-9-17)30-40(35,39-18-10-6-3-7-11-18)37-15-19-21(32)25(26,27)23(38-19)31-13-12-20(28)29-24(31)34/h2-13,16,19,21,23,32H,14-15H2,1H3,(H,30,35)(H2,28,29,34)/t16-,19+,21+,23+,40?/m0/s1
InChiKey NHTKGYOMICWFQZ-KKQYNPQSSA-N
CID 11169170
Short Description DNA synthesis inhibitor

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