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Gemcitabine hydrochloride
- dFdC - 2’,2’-difluorodeoxycytidine - LY 188011
Axon 3233
- Parent CAS: 95058-81-4
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C9H11F2N3O4.HCl
- MW: 299.66
Description
Gemcitabine hydrochloride, a deoxycytidine analogue, is an antimetabolite and a specific inhibitor of DNA synthesis. Gemcitabine hydrochloride exhibits good activity against human leukemic cell lines and murine solid tumors Moreover, Gemcitabine hydrochloride has shown activity against a wide spectrum of human solid tumors including nonsmall cell lung, pancreatic, colon, breast, bladder, ovarian, head and neck, cervical and hepatocellular cancers.
More Information
| Parent CAS No. | 95058-81-4 |
|---|---|
| Chemical Name | 4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride |
| SMILES | C1(=O)N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F.Cl |&1:8,10,13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1 |
| InChiKey | OKKDEIYWILRZIA-OSZBKLCCSA-N |
| CID | 60749 |
| Short Description | DNA synthesis inhibitor |
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