Oprozomib
- ONX-0912 - PR-047
Axon 3849
CAS:
935888-69-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C25H32N4O7S
- MW: 532.61
Description
Oprozomib, a tripeptide epoxyketone, is an orally active and irreversible inhibitor of 20S proteasome, targeting primarily chymotrypsin-like activity. It inhibits growth and induces apoptosis in MM (multiple myeloma) cells resistant to conventional and bortezomib therapies. Its anti-MM activity is associated with activation of caspase-8, caspase-9, caspase-3, and poly(ADP) ribose polymerase, as well as inhibition of migration of MM cells and angiogenesis.
More Information
| Parent CAS No. | 935888-69-0 |
|---|---|
| Chemical Name | N-((S)-3-Methoxy-1-((S)-3-methoxy-1-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(SC(C)=NC=1)C(=O)N[C@@]([H])(COC)C(=O)N[C@@]([H])(COC)C(=O)N[C@](CC1C=CC=CC=1)([H])C(=O)[C@]1(CO1)C |&1:9,17,25,36,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1 |
| InChiKey | SWZXEVABPLUDIO-WSZYKNRRSA-N |
| CID | 25067547 |
| Short Description | Proteasome inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2256 | Biotinyl-phenylboronic acid |
From $319.00 |
| 2257 | Dansyl-PEG-phenylboronic acid |
From $396.00 |
| 4218 | Carfilzomib |
From Inquiry |
Other Categories
Get a Quote for
Loading...