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PTX80

Axon 3639
CAS:  2376297-69-5
Purity:  98%
  • Soluble in DMSO
  • MF:  C26H26N4O3S
  • MW:  474.57

Description

PTX80 is a first-in-class inhibitor of protein degradation by targeting the autophagy receptor p62/SQSTM1. PTX80 binds to p62, inducing a decrease in soluble p62 and formation of insoluble p62 aggregates, and failure of polyubiquitinated proteins to colocalize with p62. PTX80 induces proteotoxic stress and activation of unfolded protein response, which, in turn, leads to apoptosis.

More Information

Parent CAS No. 2376297-69-5
Chemical Name 4,4'-(1E,1'E)-(1-(3-(Dimethylamino)propylsulfonyl)-4-oxopiperidine-3,5-diylidene)bis(methan-1-yl-1-ylidene)dibenzonitrile
SMILES C1(=C/C2C=CC(C#N)=CC=2)C(=O)/C(=C/C2C=CC(C#N)=CC=2)/CN(S(CCCN(C)C)(=O)=O)C1
MFCD N.A.
InChi InChI=1S/C26H26N4O3S/c1-29(2)12-3-13-34(32,33)30-18-24(14-20-4-8-22(16-27)9-5-20)26(31)25(19-30)15-21-6-10-23(17-28)11-7-21/h4-11,14-15H,3,12-13,18-19H2,1-2H3/b24-14+,25-15+
InChiKey ACOAFAKBTXAOQG-KOJZRSEWSA-N
CID 139476669
Short Description p62/SQSTM1 ligand

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