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Simvastatin
- MK733 - Synvinolin
Axon 3443
CAS:
79902-63-9
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C25H38O5
- MW: 418.57
Description
Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.2 nM.
More Information
| Parent CAS No. | 79902-63-9 |
|---|---|
| Chemical Name | (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| SMILES | C1[C@H](OC(C(C)(C)CC)=O)[C@]2([H])[C@@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H](C)C=CC2=C[C@@H]1C |&1:1,10,12,15,17,23,29,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 |
| InChiKey | RYMZZMVNJRMUDD-HGQWONQESA-N |
| CID | 54454 |
| Short Description | HMG-CoA inhibitor |
References
- WC Duane et al. Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile. Hepatology. 1988 Sep-Oct;8(5):1147-50.
- EE Slater et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs. 1988;36 Suppl 3:72-82.
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