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RO-0711401
Axon 3422
CAS:
714971-87-6
Purity:
99%
- Soluble in DMSO
- MF: C18H11F3N2O3
- MW: 360.29
Description
RO-0711401 is a potent and orally available positive allosteric modulator (PAM) of the mGlu1 receptor with an IC50 value of 56 nM.
More Information
| Parent CAS No. | 714971-87-6 |
|---|---|
| Chemical Name | N-(4-(Trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide |
| SMILES | C12C=CC=CC=1OC1C=CC=CC=1C2C(=O)NC1OC=C(C(F)(F)F)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24) |
| InChiKey | GSGDLBUOSWGZER-UHFFFAOYSA-N |
| CID | 10338547 |
| Short Description | mGluR1 PAM |
References
- E Vieira et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9.
- PM Garcia-Barrantes et al. Re-exploration of the mGlu₁ PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR. Bioorg Med Chem Lett. 2016 May 1;26(9):2289-92.
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