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ADH-503
- Leukadherin-1 choline salt - LA1
Axon 3048
- Parent CAS: 2055362-72-4
Purity:
99%
- Soluble in DMSO
- MF: C22H14NO4S2.C5H14NO
- MW: 524.65
Description
ADH-503 is an allosteric agonist of integrin CD11b/CD18 (also known as Mac-1) with an EC50 value of 4 mM. ADH-503 suppresses myeloid cell infiltration into inflamed or infected sites by increasing CD11b-dependent cell adhesion to ICAM-1 on the endothelium, preventing subsequent extravasation. Moreover, partial activation of CD11b by ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhanced dendritic cell responses.
More Information
| Parent CAS No. | 2055362-72-4 |
|---|---|
| Chemical Name | 2-Hydroxy-N,N,N-trimethylethanaminium (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate |
| SMILES | C1(C2OC(/C=C3/C(=O)N(CC4C=CC=CC=4)C(=S)S/3)=CC=2)C=CC(C([O-])=O)=CC=1.[N+](C)(C)(C)CCO |
| MFCD | N.A. |
| InChi | InChI=1S/C22H15NO4S2.C5H14NO/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26;1-6(2,3)4-5-7/h1-12H,13H2,(H,25,26);7H,4-5H2,1-3H3/q;+1/p-1/b19-12-; |
| InChiKey | GOWDQYRMBCOOJR-JHMJKTBASA-M |
| CID | 145711124 |
| Short Description | CD11b/CD18 agonist |
References
- RZ Panni et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies. Sci Transl Med. 2019 Jul 3;11(499).
- I Dickson. CD11b agonism overcomes PDAC immunotherapy resistance. Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):514.
- D Maiguel et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal. 2011 Sep 6;4(189):ra57.
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