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(R)-CE3F4
Axon 2830
CAS:
1593478-56-8
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C11H10Br2FNO
- MW: 351.01
Description
(R)-CE3F4 is a stereoselective inhibitor of EPAC1 (RAPGEF3) with an IC50 value of 5.8 µM and approximately 10-fold selectivity over EPAC2. It inhibits the guanine-nucleotide exchange activity of EPAC1 rather than blocking cAMP-dependent protein kinase.
(R)-CE3F4 prevents EPAC1 activation in biochemical systems and living cells, enabling selective investigation of EPAC1–Rap signaling in adhesion, migration, vascular responses and cAMP compartmentalization. The racemate is available as CE3F4 (Axon 2929).
Key Features
- Stereoselective EPAC1 inhibitor
- IC50: 5.8 µM
- Approximately 10-fold selectivity over EPAC2
- Blocks EPAC1 guanine-nucleotide exchange activity
Applications
- EPAC1 and RAPGEF3 research
- cAMP–Rap signaling studies
- Cell adhesion and migration assays
- Vascular signaling research
- Enantiomer and racemate comparisons
More Information
| Parent CAS No. | 1593478-56-8 |
|---|---|
| Chemical Name | (R)-5,7-Dibromo-6-fluoro-2-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde |
| SMILES | C1(F)C(Br)=C2CC[C@@H](C)N(C=O)C2=CC=1Br |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m1/s1 |
| InChiKey | ZZLQPWXVZCPUGC-ZCFIWIBFSA-N |
| CID | 73669655 |
| Short Description | EPAC1 inhibitor |
(R)-CE3F4
stereoselective EPAC1 inhibitor
EPAC
stereoselective EPAC1
Inhibitor
cAMP signaling
EPAC1 and RAPGEF3 research
cAMP–Rap signaling studies
Cell adhesion and migration assays
Vascular signaling research
Enantiomer and racemate comparisons
vascular biology
kinase signaling
receptor selectivity
signal transduction
cAMP
CAS 1593478-56-8
Axon Medchem
Axon 2830
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