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ML 154
- NCGC 00185684 - NCGC 84
Axon 2321
- Parent CAS: 1346105-73-4
Purity:
99%
- Soluble in DMSO
- MF: C29H26N2PS.Br
- MW: 545.47
Description
ML 154 (NCGC00185684) is a competitive, selective and brain-penetrant neuropeptide S receptor (NPSR) antagonist with IC50 values of 22.1 nM, 36.5 nM and 5.0 nM in Ca2+, cAMP and binding assays, respectively. It preferentially blocks NPS-induced ERK phosphorylation and decreases alcohol self-administration in vivo.
NPSR signaling regulates arousal, anxiety-like behavior, reward circuitry and alcohol-seeking behavior through GPCR-linked pathways. ML 154 is useful for studying NPSR antagonist pharmacology and addiction-related neurobehavioral mechanisms.
Key Features
- Selective NPS receptor antagonist
- IC50: 5.0 nM in binding assays
- Brain-penetrant pharmacological profile
- Reduces alcohol self-administration in reported in vivo studies
Applications
- NPSR pharmacology
- Addiction and alcohol-seeking research
- ERK and cAMP signaling assays
- Neuropeptide GPCR studies
More Information
| Parent CAS No. | 1346105-73-4 |
|---|---|
| Chemical Name | 1-cinnamyl-3-(diphenylphosphorothioyl)-2-methyl-1H-imidazo[1,2-a]pyridin-4-ium bromide |
| SMILES | C12=[N+](C/C=C/C3=CC=CC=C3)C(C)=C(P(C3=CC=CC=C3)(C3=CC=CC=C3)=S)N1C=CC=C2.[Br-] |
| MFCD | N.A. |
| InChi | InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+; |
| InChiKey | CJAQCMBWGUOBIX-ZUQRMPMESA-M |
| CID | 46930969 |
| Short Description | NPS antagonist |
